PIAS 1 Polyclonal Antibody, 50ul Buffers & Solutions Overexpression of this protein delayes

Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor

thus may function in signaling pathways utilized broadly during fetal development

a protein involved in the initiation of DNA replication

Mutations in this gene are associated with ectodermal dysplasia

The encoded protein forms a complex with alpha-2

PIAS 1 Polyclonal Antibody, 50ul Buffers & Solutions Overexpression of this protein delayesPIAS1 encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Protein inhibitor of activated STAT 1 plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript