XRCC3 Polyclonal Antibody, 100ul[BT-AP09626] Dry Bath A chromosomal translocation and gene

A chromosomal translocation and gene fusion between this gene and zinc finger| MIZ-type containing 1 (Gene ID: 57178) may underlie intellectual disability and neuropsychiatric problems in a human patient

Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons

The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization

located on chromosomes 7 and 13

VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm

XRCC3 Polyclonal Antibody, 100ul[BT-AP09626] Dry Bath A chromosomal translocation and geneXRCC3 encodes a member of the RecA Rad51 related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair deficient mutant that exhibits hypersensitivity to a number of different DNA damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying