Rock-1 Polyclonal Antibody, 50ul[BT-AP13880] Purification SIM1 transcript was detected only

SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested

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A transcribed pseudogene of this gene has been identified on chromosome 15

Mutations in this gene have been associated with autosomal recessive mental retardation

It has now been found that this gene is involved in the regulation of many NR and non-NR activities

Rock-1 Polyclonal Antibody, 50ul[BT-AP13880] Purification SIM1 transcript was detected onlyThis gene encodes a protein serine threonine kinase that is activated when bound to the GTP bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP bound form and the active GTP bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response