Dok-2 Polyclonal Antibody, 50ul[BT-AP02698] Hybridoma Antibody Sequencing Required for proper 27S pre-rRNA

Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly

A second copy of this gene within the centromeric copy of the duplication has been described in the literature

subcellular location:Expressed diffusely throughout the nucleus

Mutations in this gene are associated with generalized glucocorticoid resistance

The protein may also be involved in the pathophysiology of depression

Dok-2 Polyclonal Antibody, 50ul[BT-AP02698] Hybridoma Antibody Sequencing Required for proper 27S pre-rRNAThe protein encoded by DOK2 (docking protein 2)is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.