JIP-1 Polyclonal Antibody, 100ul Immune Cell Analysis The protein encoded by KLF7

The protein encoded by KLF7 (Kruppel like factor 7)is a member of the Kruppel-like transcriptional regulator family

but is found in a wide range of cultured cell lines

but activates transcription when Ras is present

This suggests this gene product may function as a tumor suppressor

Multiple polyadenylation sites of this gene have been reported

JIP-1 Polyclonal Antibody, 100ul Immune Cell Analysis The protein encoded by KLF7MAPK8IP1 encodes a regulator of the pancreatic beta cell function. C Jun amino terminal kinase interacting protein 1 is highly similar to JIP 1, a mouse protein known to be a regulator of c Jun amino terminal kinase (Mapk8). C Jun amino terminal kinase interacting protein 1 has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL 1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells.