Septin 7 Polyclonal Antibody, 50ul Serum & Sample Tubes Mutations in this gene have

Mutations in this gene have been associated with chronic granulomatous disease

All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner

Alternative splicing results in two transcript variants encoding distinct isoforms

Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7)

Significant expression of this protein has been observed in the placenta

Septin 7 Polyclonal Antibody, 50ul Serum & Sample Tubes Mutations in this gene haveSEPT7 encodes septin 7 that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in