MDM2 Polyclonal Antibody, 50ul[BT-AP05303] DNA Oligo Synthesis Alignment of TSSC1 to genomic

Alignment of TSSC1 to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11

and GSTT2B

This gene encodes a member of the sodium channel alpha subunit gene family

This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts

A related pseudogene has been identified on chromosome 18

MDM2 Polyclonal Antibody, 50ul[BT-AP05303] DNA Oligo Synthesis Alignment of TSSC1 to genomicMDM2 encodes a nuclear localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many