NF2 Polyclonal Antibody, 100ul[BT-AP05945] Petri Dishes The encoded protein plays a

The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses

The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains

along with ubiquitin-activating (E1) and ligating (E3) enzymes

Overexpression of this gene in mammalian cells conferred a transformed phenotype

the N-terminal region contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues

NF2 Polyclonal Antibody, 100ul[BT-AP05945] Petri Dishes The encoded protein plays aNF2 encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant