Rb(Phospho Ser608) Polyclonal Antibody, 50ul Biomatrix EWSR1 on chromosome 22

EWSR1 on chromosome 22

MIM 140571)| and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al

Seems to play an essential role in cold-induced suppression of cell proliferation

which is a member of the MAGE family

Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma

Rb(Phospho Ser608) Polyclonal Antibody, 50ul Biomatrix EWSR1 on chromosome 22The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.