ADAM10 Polyclonal Antibody, 50ul PCR Series a putative tumor suppressor associated

a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1

The main portion of the receptor is a heterodimer composed of 2 polypeptide chains

Constitutive activation of this gene caused either by somatic mutations

Members of the WD40 repeat family are key components of many essential biologic functions

Mutations in ROR2 can cause brachydactyly type B

ADAM10 Polyclonal Antibody, 50ul PCR Series a putative tumor suppressor associatedMembers of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. ADAM10 encodes and ADAM family member that cleaves many proteins including TNF alpha and E cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing.