Chk1(Phospho Ser345) Polyclonal Antibody, 100ul Lysosome RYR2 (ryanodine receptor 2) encodes

RYR2 (ryanodine receptor 2) encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum

This protein is overexpressed in fetal Down syndrome brain

Capacity：5mL x 6

While the long isoform (22 kDa) acts as an activator| the short isoform (14 kDa) has been shown to repress gamma-globin gene expression

and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17

Chk1(Phospho Ser345) Polyclonal Antibody, 100ul Lysosome RYR2 (ryanodine receptor 2) encodesThe protein encoded by this gene belongs to the Ser Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells