TBP Polyclonal Antibody, 20ul Biochemical Reagents Suppressor of cytokine signaling 2

Suppressor of cytokine signaling 2 encoded by SOCS2 interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling

Interacts with RIN2 and RIN3

It is a tetramer composed of 1 alpha| 1 beta| and 2 gamma chains

The active form of the protein is found extracellularly as a homodimer

This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis

TBP Polyclonal Antibody, 20ul Biochemical Reagents Suppressor of cytokine signaling 2Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA binding protein (TBP) and a group of