ERCC2 Polyclonal Antibody, 20ul PCR Series The encoded proteins binds to

The encoded proteins binds to its own promoter as well as to that of several target genes

This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit

have been reported in a variety of solid tumors

and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis

but not IL2

ERCC2 Polyclonal Antibody, 20ul PCR Series The encoded proteins binds toThe nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2 TFIIH complex. The gene product has ATP dependent DNA helicase activity and belongs to the RAD3 XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer prone syndrome