MIM1 oitin sulfate Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85

Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85

is a potent and specific aryl hydrocarbon receptor (AhR) antagonist

This strategy preferentially targets primary Bcr/Abl(+) hematopoietic cells and exhibits enhanced in vivo activity

Y-27632 is typically used at 10 μM concentration in cell culture

Ingenol Mebutate (PEP005) activates PKCδ and inhibits PKCα

MIM1 oitin sulfate Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85MIM1 is an inhibitor of Mcl 1, an antiapoptotic Bcl 2 family protein that selectively engages the canonical groove of Mcl 1, inhibiting its ability to bind BH3 domains. MIM1 induces caspase 3 7 activation and cell death in Mcl 1 dependent leukemia cells. Product information CAS Number: 509102 00 5 Molecular Weight: 347. 43 Formula: C17H21N3O3S Synonym: MIM 1 MIM 1 Inhibitor of Mcl 1 Chemical Name: 4 [(1E) {[2 (cyclohexylimino) 4 methyl 2,3 dihydro 1,3